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科学家发现一种分子可以摧毁小鼠体内最严重的癌症_我的网站

A |     Kareena Kapoor Khan has been one of Bollywood’s most beloved actresses for over two decades. She made her debut in 2000 opposite Abhishek Bachchan in Refugee and has since captivated audiences with a wide range of performances. From romantic comedies to intense dramas, the actress has delivered roles that are not only memorable but have also become a part of Bollywood's pop culture. Here’s a look at some of her unmissable films that showcase her range and talent.     In This Article      Refugee (2000)Kabhi Khushi Kabhie Gham (2001)Chameli (2004)Omkara (2006)Chup Chup Ke (2006)Jab We Met (2007)Heroine (2012)Udta Punjab (2016)Crew (2023)Refugee (2000)          Kareena Kapoor made her Bollywood debut with Refugee alongside Abhishek Bachchan. The film, directed by JP Dutta, tells the story of two young people caught in the complex world of human trafficking along the India-Pakistan border. The actress played Nazneen, a spirited and determined young woman who falls in love with Abhishek’s character, known as 'Refugee'. He helps illegal refugees from India and Pakistan cross the border through the Great Rann of Kutch. Even as a debutant, her performance was confident and graceful, and the actress won the Filmfare Award for Best Female Debut.     Kabhi Khushi Kabhie Gham (2001)                                                  Karan Johar's Kabhi Khushi Kabhie Gham remains one of Kareena Kapoor’s most iconic films. She played the effervescent Pooja, also known as Poo. The actress' portrayal of the stylish and confident Poo became instantly memorable and is still celebrated today. The film featured an ensemble cast including Shah Rukh Khan, Amitabh Bachchan, Jaya Bachchan, Hrithik Roshan, and Kajol. Her comic timing, style, and energy made Poo a character that defined a generation of Bollywood fashion and pop culture.     Chameli (2004)          Chameli was a turning point in Kareena Kapoor's career, where she took on a much darker and unconventional role. She played Chameli, a street-smart sex worker, opposite Rahul Bose in a rain-soaked, single-night narrative. Her performance was intense and emotionally grounded, showcasing a depth rarely seen in her earlier work. The actress won the Special Award for Best Performance at the Filmfare Awards.     Omkara (2006)                                                  Omkara is Vishal Bhardwaj’s adaptation of Shakespeare’s Othello. Kareena played Dolly, a loyal and innocent woman caught in a story of jealousy, betrayal, and tragedy. She starred alongside Ajay Devgn, Saif Ali Khan, Vivek Oberoi and Konkona Sen Sharma. Kareena delivered a nuanced performance that suited the dark and complex narrative. She won the Filmfare Award for Best Actress (Critics) for Omkara.     Chup Chup Ke (2006)                                              Chup Chup Ke is a comedy-drama directed by Priyadarshan, in which Kareena Kapoor plays Shruti Singh Chauhan, a young woman who is mute and becomes central to the film’s twists and comic moments. The story follows Jeetu (Shahid Kapoor), a debt‑ridden young man who, overwhelmed by financial pressure, decides to fake his own death to help his family claim insurance money. Rescued by two fishermen who mistakenly believe he is mute and wealthy, Jeetu begins pretending not to speak or hear to maintain the misunderstanding. This leads him to the household of Shruti and her affluent family. The film also stars Suniel Shetty, Neha Dhupia, Paresh Rawal, Rajpal Yadav and Om Puri among others.     Jab We Met (2007)               Jab We Met remains one of Kareena’s most beloved films. In the Imtiaz Ali directorial, she played Geet, a lively, talkative, and spirited young woman who meets a heartbroken businessman, Aditya (played by Shahid Kapoor), on a train journey. Their interaction changes the course of both their lives. Her charm, energy, and comic timing were effortless, and the character became iconic in Bollywood cinema. Kareena’s dialogues and looks from the film have become a part of the pop culture.       Heroine (2012)                                                  Madhur Bhandarkar's Heroine saw Kareena play Mahi Arora, a once-successful actress whose personal life and career are on the decline. To bring her career back on track, she hires a public relations manager, who uses sensationalist tactics to keep Mahi in the spotlight. However, certain events and life-changing controversies led to her quitting the film industry. The film explores the pressure of stardom, the reality underneath the glamour and the emotional toll of living in a world where public image means everything. While it received mixed reviews, Kareena's performance was lauded by fans and critics. Heroine also starred Arjun Rampal, Randeep Hooda, Divya Dutta, Govind Namdev and Sanjay Suri among others.     Udta Punjab (2016)                                                  In Udta Punjab, Kareena Kapoor took on a socially relevant role as Dr Preet Sahni, a compassionate doctor working to combat drug abuse in Punjab. The film, also starring Shahid Kapoor, Alia Bhatt, and Diljit Dosanjh, addressed a pressing societal issue.       Crew (2023)                                              Crew, directed by Rajesh A Krishnan, is a heist comedy where Kareena Kapoor Khan stars alongside Tabu and Kriti Sanon as three flight attendants who work for a struggling airline. When the trio accidentally uncovers a gold-smuggling operation on one of their flights, they decide to turn the tables and devise a dangerous plan to outsmart the criminals and secure the treasure. The film blends comedy, suspense, and teamwork. Kareena’s performance balances charm and comic timing with a sense of cleverness, making her a standout in this female-led ensemble.          Also Read: Kareena Kapoor Khan Teases Meghna Gulzar With a Fun Travel Update From Daayra Shoot。    这种新的分子癌症治疗方法依赖于一种特定的分子，它可以寻找围绕癌细胞的酸性环境。但是，为了使细胞有足够的酸性，它们不能是“冷”的肿瘤，这种肿瘤几乎没有免疫活性。这就是被称为STING激动剂的药物发挥作用的地方。这些药物使肿瘤“燃烧”起来，允许免疫系统对其作出反应。然而，找到"冷"癌细胞可能很困难。这就是新的分子癌症疗法发挥作用的地方。研究人员本月在《肿瘤学前沿》（Frontiers of Oncology）杂志上发表了一项关于该分子的研究。根据该研究，该分子被称为pH值低的插入肽（pHLIP），它被吸引到酸性环境。通过使用该分子引导药物到肿瘤和癌细胞，他们能够将它们踢出"寒冷"的肿瘤范围，推动免疫系统进行反击。然后，他们可以使用免疫检查点抑制剂来有效地移除使免疫系统不至于用力过猛的自然刹车。这种分子癌症治疗方法让免疫系统更长时间地对抗癌症。这是一个双重的系统，基本上允许研究人员准确地引导药物到它们需要的地方。近年来，我们已经看到越来越多像这种新的分子癌症治疗方法这样的靶向选择出现了。

B | 一种针对癌细胞的病毒也一直在进行，我们甚至看到研究人员在测试一种能杀死皮肤癌的凝胶。在测试分子癌症治疗方法时，研究人员将pHLIP与STING激动剂耦合在一起，然后对20只患有结肠直肠肿瘤的小鼠进行治疗。他们发现，在一次注射后，18只小鼠的肿瘤在几天内完全消失。在另一组有较大肿瘤的小鼠中，他们看到接受治疗的10只小鼠中有7只肿瘤消失了。

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